期刊
AMERICAN JOURNAL OF KIDNEY DISEASES
卷 63, 期 6, 页码 997-1006出版社
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1053/j.ajkd.2013.10.052
关键词
Anemia; end-stage renal disease; hemodialysis; hemoglobin concentration; red blood cell transfusion
资金
- Amgen, Inc,Thousand Oaks, CA
Background: Changes in anemia management practices due to concerns about erythropoiesis-stimulating agent safety and Medicare payment changes may increase patient risk of transfusion. We examined anemia management trends in hemodialysis patients and risk of red blood cell (RBC) transfusion according to dialysis facility-level hemoglobin concentration. Study Design: Retrospective follow-up study; 6-month study period (January to June), 3-month exposure/follow-up. Setting & Participants: For each year in 2007-2011, annual cohorts of point-prevalentMedicare primary payer patients receiving hemodialysis on January 1with one ormore hemoglobinmeasurements during the study period. Annual cohorts averaged 170,000 patients, with 130,000 patients and 3,100 facilities for the risk analysis. Predictor: Percentage of facility patient-months with hemoglobin level, 10 g/dL. Outcome: Patient-level RBC transfusion rates. Measurements: Monthly epoetin alfa and intravenous iron doses, mean hemoglobin levels, and RBC transfusion rates; percentage of facility patient-months with hemoglobin levels, 10 g/dL (exposure) and patient-level RBC transfusion rates (follow-up). Results: Percentages of patients with hemoglobin levels, 10 g/dL increased every year from 2007 (6%) to 2011 (similar to 11%). Epoetin alfa doses, iron doses, and transfusion rates remained relatively stable through 2010 and changed in 2011. Median monthly epoetin alfa and iron doses decreased 25% and 43.8%, respectively, and monthly transfusion rates increased from 2.8% to 3.2% in 2011, a 14.3% increase. Patients in facilities with the highest prevalence of hemoglobin levels, 10 g/dL over 3 months were at similar to 30% elevated risk of receiving RBC transfusions within the next 3 months (relative risk, 1.28; 95% CI, 1.22-1.34). Limitations: Possibly incomplete claims data; smaller units excluded; hemoglobin levels reported monthly for patients receiving epoetin alfa; transfusions usually not administered in dialysis units. Conclusions: Dialysis facility treatment practices, as assessed by percentage of patient-months with hemoglobin levels, 10 g/dL over 3 months, were associated significantly with risk of transfusions in the next 3 months for all patients in the facility, regardless of patient case-mix. (C) 2014 by the National Kidney Foundation, Inc.
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