Musical Disorders: From Behavior to Genes

Research over the last decade has provided compelling evidence that the ability to engage with music is a fundamental human trait, yet the biological basis of music remains largely unknown. Recent findings indicate that a small number of individuals have severe musical problems that have neurogenetic underpinnings. Such deficiencies are termed congenital amusia, an umbrella term for lifelong musical disabilities that cannot be attributed to mental retardation, deafness, lack of exposure to music, or brain damage after birth. Congenital amusia constitutes a natural experiment, giving us a rare chance to examine the biological basis of music by tracing causal links among genes, environment, brain, and behavior.