期刊
AMERICAN JOURNAL OF KIDNEY DISEASES
卷 55, 期 5, 页码 928-940出版社
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1053/j.ajkd.2009.11.021
关键词
Diabetic nephropathy; therapy; advanced glycation
资金
- US Public Health Service [DK55801]
- National Institute of Diabetes and Digestive and Kidney Diseases
- NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES [R01DK055801] Funding Source: NIH RePORTER
Diabetic nephropathy is the leading cause of end-stage renal disease, and both the incidence and prevalence of diabetic nephropathy continue to increase. Currently, various treatment regimens and combinations of therapies provide only partial renoprotection. It is obvious that new approaches are desperately needed to retard the progression of diabetic nephropathy. Recently, a number of new agents have been described that have the potential to delay the progression of diabetic kidney disease and minimize the growing burden of end-stage renal disease. These include inhibitors and breakers of advanced glycation end products, receptor antagonists for advanced glycation end products, protein kinase C inhibitors, NADPH (reduced nicotinamide adenine dinucleotide phosphate) oxidase inhibitors, glycosaminoglycans, endothelin receptor antagonists, antifibrotic agents, and growth factor inhibitors. This review addresses these promising new therapeutic agents for delaying the progression of diabetic kidney disease. Am J Kidney Dis 55:928-940. (C) 2010 by the National Kidney Foundation, Inc.
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