期刊
AMERICAN JOURNAL OF INFECTION CONTROL
卷 40, 期 2, 页码 108-112出版社
MOSBY-ELSEVIER
DOI: 10.1016/j.ajic.2011.03.010
关键词
Health care-acquired infection; Molecular typing; Clonal dissemination
资金
- National Institute of Science and Technology [014/2008]
- National Institute of Science and Technology for Health Technology Assessment (IATS)-CNPq/Brazil
Background: Most published data on multidrug-resistant Acinetobacter baumanii (MDR Ab) are derived from outbreaks. We report incidence trends on health careeacquired infections due to MDR Ab over a 12-month period in the city of Porto Alegre in southern Brazil. Methods: Clinical and epidemiologic data were obtained from the local health care information system of the municipal health department. Polymerase chain reaction was used to detect the presence of the genes bla(OXA-23-like), bla(OXA-24-like), bla(OXA-51), and bla(OXA-58), and repetitive sequence-based polymerase chain reaction and pulsed-field gel electrophoresis were performed for molecular typing. Results: The highest rate of infection (9.0/1,000 inpatient-days) was identified in a trauma hospital. The gene blaOXA-23-like was identified in 99.0% of MDR Ab isolates. Eight main clonal groups were identified by molecular typing, and 3 of these were found in all hospitals. Conclusion: The presence of 3 clones in all hospitals demonstrates the ability of MDR Ab to spread among hospitals. Moreover, the occurrence of one particular clone (clone 4) throughout the study period suggests its increased ability to cause outbreaks and to remain in the environment. The monitoring of epidemic strains by molecular methods is of paramount importance to prevent or reduce the spread of MDR Ab. Copyright (C) 2012 by the Association for Professionals in Infection Control and Epidemiology, Inc. Published by Elsevier Inc. All rights reserved.
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