Antibiotic resistance determinants in Acinetobacter spp and clinical outcomes in patients from a major military treatment facility

We explored the association of antibiotic-resistant phenotypes and genotypes in Acinetobacter spp with clinical outcomes and characteristics in 75 patients from a major military treatment facility. Amikacin resistance was associated with nosocomial acquisition of A baumannii, and carbapenem resistance and bla(OXA-23) were associated with the need for mechanical ventilation. The presence of bla(OXA-23) also correlated with longer hospital and ICU stay. Associations between bla(OXA-23) and complexity, duration, and changes made to antibiotic regimens also existed. Copyright (C) 2010 by Elsevier Inc on behalf of the Association for Professionals in Infection Control and Epidemiology, Inc. (Am J Infect Control 2010; 38: 63-5.)