期刊
AMERICAN JOURNAL OF INFECTION CONTROL
卷 38, 期 1, 页码 26-30出版社
MOSBY-ELSEVIER
DOI: 10.1016/j.ajic.2009.03.015
关键词
Norovirus; feline calicivirus; disinfectants; alcohol; quaternary compounds; acids; bleach; pH; short contact time
资金
- Reckitt Benckiser Inc., Research and Development
Background: Among other measures, handwashing and targeted disinfection are important in preventing and controlling norovirus outbreaks. Presently, there are a limited number of disinfectants effective against norovirus. There is a need to develop alternatives to bleach that are effective against norovirus, and, in particular, fast-acting disinfectants are desired. The aim of this study was to determine the disinfectant actives and formulation factors necessary to achieve efficacy against norovirus in a short contact time. Methods: Feline calicivirus (FCV) was used as a surrogate for norovirus. In a carrier test method, common disinfectant actives including alcohol, acid, quaternary compound, and phenol both alone and as formulated disinfectants were contacted with dried FCV virus for 1 minute. The virus treatment was neutralized and assayed in Crandell-Reese kidney cells for cytopathic effect. Log(10) virus inactivation was calculated comparing treatment results to virus control titer. Results: Bleach and acid-based disinfectants inactivate FCV in 1 minute. Inactivation of FCV by alcohol and quaternary actives depends on how these actives are formulated as disinfectants. Actives and extreme pH are determined predictive of efficacy. Ethanol and quaternary compounds formulated at appropriate concentration and alkaline pH inactivates FCV in 1-minute contact. Conclusion: Acid cleaners, ethanol, and quaternary compounds formulated at appropriate concentration and pH can be fast-acting antimicrobial choices and alternatives to bleach for the consumer and health care providers to use to inactivate FCV, a surrogate for norovirus, and protect against this important pathogen.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据