期刊
AMERICAN JOURNAL OF INDUSTRIAL MEDICINE
卷 54, 期 3, 页码 175-184出版社
WILEY
DOI: 10.1002/ajim.20924
关键词
a case control etiologic study of sarcoidosis (ACCESS); forced vital capacity (FVC); granulomatous disease; sarcoidosis; World Trade Center (WTC)
资金
- CDC/NIOSH [200-2002-00384, U1O 0H008232, U10 OH008225, U10 OH008239, U10 OH008275, OH008216, U10 OH008223]
- ALLCDC
- NIOSH [553948, 3U10OH008239-05S1, 557746, 568749] Funding Source: Federal RePORTER
- NIOSH
- ALLCDC [3U10OH008239-04S2, 3U10OH008239-05S5] Funding Source: Federal RePORTER
Background More than 20,000 responders have been examined through the World Trade Center (WTC) Medical Monitoring and Treatment Program since September 11, 2001. Studies on WTC firefighters have shown elevated rates of sarcoidosis. The main objective of this study was to report the incidence of sarcoid like granulomatous pulmonary disease in other WTC responders. Methods Cases of sarcoid like granulomatous pulmonary disease were identified by: patient self-report, physician report and ICD-9 codes. Each case was evaluated by three pulmonologists using the ACCESS criteria and only definite cases are reported. Results Thirty-eight patients were classified as definite cases. Six-year incidence was 192/100,000. The peak annual incidence of 54 per 100,000 person-years occurred between 9/11/2003 and 9/11/2004. Incidence in black responders was nearly double that of white responders. Low FVC was the most common spirometric abnormality. Conclusions Sarcoid like granulomatous pulmonary disease is present among the WTC responders. While the incidence is lower than that reported among firefighters, it is higher than expected. Am. J. Ind. Med. 54: 175-184, 2011. (c) 2010 Wiley-Liss, Inc.
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