期刊
EMERGING INFECTIOUS DISEASES
卷 14, 期 11, 页码 1693-1699出版社
CENTERS DISEASE CONTROL & PREVENTION
DOI: 10.3201/eid1411.080381
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资金
- NIAID NIH HHS [R01 AI067584, 1R01AI067584-01A2, R01 AI040481, R01 AI40481-01A1] Funding Source: Medline
- PHS HHS [R01 CCR523379] Funding Source: Medline
- NCPDCID CDC HHS [R01 CI000373, R01 CI000373-01, 1 U01 CI000384-01, U01 CI000384] Funding Source: Medline
USA300 is the dominant strain responsible for community-associated (CA) methicillin-resistant Staphylococcus aureus (MRSA) infections in most of the United States. We examined isolates from outbreaks of MRSA skin infections in rural southwestern Alaska in 1996 and 2000 (retrospective collection) and from the hospital serving this region in 2004-2006 (prospective collection). Among 36 retrospective collection isolates, 92% carried Panton-Valentine leukocidin (PVL) genes; all carried staphylococcal chromosomal cassette mec (SCCmec) type IV. None belonged to clonal complex (CC) 8, the CC associated with USA300; 57% were sequence type (ST) 1, and 26% were ST30; 61% were clindamycin resistant. In the prospective collection, 42 isolates were PVL+ and carried SCCmec type IV; 83.3% were ST1, 9.5% were ST30, and 7.1% were ST8. Among 120 prospective isolates, 57.5% were clindamycin resistant. CA-MRSA epidemiology in southwestern Alaska differs from that in the lower 48 states; ST8 strains were rarely identified and clindamycin resistance was common.
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