期刊
AMERICAN JOURNAL OF HYPERTENSION
卷 26, 期 9, 页码 1140-1147出版社
OXFORD UNIV PRESS
DOI: 10.1093/ajh/hpt083
关键词
blood pressure; Chlamydia pneumoniae; cytomegalovirus; Helicobacter pylori; herpes simplex virus; hypertension; pathogen
资金
- Ministry of Health [02.01.01.01.ACS 2002-03]
- World Health Organization Regional Office for the Eastern Mediterranean [02.01.01.01.ACS 2002-03]
- Bushehr Province Research Committee
BACKGROUND Chronic infection with cytomegalovirus (CMV), Chlamydia pneumoniae, herpes simplex virus 1 (HSV-1), and Helicobacter pylori may contribute to essential hypertension. However, the evidence now available does not clarify whether the aggregate number of pathogens (pathogen burden) may be associated with hypertension. METHODS Sera from 1,754 men and women aged >= 25 years were analyzed for immunoglobulin G antibodies to C. pneumoniae, HSV-1, H. pylon,. and CMV using enzyme-linked immunosorbent assay. The aggregate number of seropositives to the studied viral and bacterial agents was defined as pathogen burden. Hypertension was defined according to World Health Organization criteria. RESULTS A total of 459 (26.3%) of the subjects had hypertension. In the hypertensive group, 4.2% had 0 or 1 pathogens present, 20.6% had 2,43.2% had 3, and 32.1% had 4; in the normotensive group, 7.9% had 0 or 1, 28.4% had 2,42.7% had 3, and 21.0% had 4. Of the 4 studied pathogens, H. pylon seropositivity showed a significant independent association with hypertension (odds ratio (OR) =1.37; 95% confidence interval (CI) =1.05-1.79; P = 0.02). In multiple logistic regression analyses, the pathogen burden did not show a significant independent association with hypertension. Coinfection with H. pylon and C. pneumoniae was significantly associated with hypertension compared with double seronegativity after adjustment for age, sex, chronic low-grade inflammation, and cardiovascular risk factors (OR = 1.68; 95% Cl = 1.14-2.47; P = 0.008). CONCLUSIONS The pathogen burden was not associated with hypertension. However, coinfection with C. pneumoniae and H. pylori showed a significant association with essential hypertension, independent of cardiovascular risk factors and chronic low-grade inflammation.
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