期刊
AMERICAN JOURNAL OF HYPERTENSION
卷 26, 期 7, 页码 888-895出版社
OXFORD UNIV PRESS
DOI: 10.1093/ajh/hpt033
关键词
alcohol; blood pressure; cardiovascular disease; dyslipidemia; hypertension; triglycerides; HDL cholesterol ratio
资金
- Japan Society for the Promotion of Science [24390171]
- Grants-in-Aid for Scientific Research [24390171] Funding Source: KAKEN
The triglycerides/high-density lipoprotein cholesterol (TG/HDL-C) ratio has been proposed to be a good predictor of cardiovascular disease. The relationship between alcohol consumption and TG/HDL-C ratio in patients with hypertension is unknown. Subjects were normotensive and hypertensive men aged 3560 years who were divided by daily ethanol intake into non-, light (< 22g/day), heavy (22 but < 44g/day), and very heavy (44g/day) drinkers. The TG/HDL-C ratio was significantly higher in the hypertensive group than in the normotensive group. Both in the normotensive and hypertensive groups, TG/HDL-C ratio was significantly lower in light, heavy, and very heavy drinkers than in nondrinkers and was lowest in light drinkers. In the hypertensive group, odds ratios (ORs) for high TG/HDL-C ratio (3.75) in light, heavy, and very heavy drinkers vs. nondrinkers were significantly lower (P < 0.01) than a reference level of 1.00 (light drinkers: OR 0.49, 95% confidence interval (CI) 0.400.59; heavy drinkers: OR 0.59, 95% CI 0.520.67; very heavy drinkers: OR 0.70, 95% CI 0.610.80) and were significantly lower than the corresponding ORs in the normotensive group. The ORs for hypertension in subjects with vs. subjects without high TG/HDL-C ratio were significantly higher than the reference level in all the alcohol groups and were significantly lower in light, heavy, and very heavy drinkers than in nondrinkers. The results suggest that there is an inverted J-shaped relationship between alcohol and TG/HDL-C ratio in individuals with hypertension and that alcohol weakens the positive association between TG/HDL-C ratio and hypertension.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据