期刊
AMERICAN JOURNAL OF HYPERTENSION
卷 25, 期 10, 页码 1124-1130出版社
OXFORD UNIV PRESS
DOI: 10.1038/ajh.2012.88
关键词
adipokine; blood pressure; essential hypertension; family history; fatty acid-binding protein; hypertension; insulin resistance
资金
- Ministry of Education, Culture, Sports, Science and Technology
- Uehara Memorial Foundation
- Mitsubishi Pharma Research Foundation
- Naito Foundation
- Takeda Science Foundation
- Mochida Memorial Foundation for Medical and Pharmaceutical Research
- Kanae Foundation for the Promotion of Medical Science
- Cardiovascular Research Foundation
- Suzuken Memorial Foundation
- Sumitomo Foundation
- Tokyo Biochemical Research Foundation
- Japan Diabetes Foundation
- Ono Medical Research Foundation
- Novartis Foundation (Japan) for the Promotion of Science
- Akiyama Life Science Foundation
- Terumo Life Science Foundation
- Daiwa Securities Health Foundation
- Suhara Memorial Foundation
- Japan Foundation for Applied Enzymology
- Ichiro Kanehara Foundation
- Grants-in-Aid for Scientific Research [23591106] Funding Source: KAKEN
BACKGROUND Fatty acid-binding protein 4 (FABP4/A-FABP/aP2), a lipid chaperone, is expressed in both adipocytes and macrophages. Recent studies have shown secretion of FABP4 from adipocytes and association of elevated serum FABP4 level with obesity, insulin resistance, and atherosclerosis. However, little is known about the role of FABP4 in essential hypertension. METHODS We first examined serum FABP4 concentrations in 18 normotensives (NT) and 30 nontreated essential hypertensives (EHT). The EHT were divided into 18 insulin-sensitive EHT (EHT-S) and 12 insulin-resistant EHT (EHT-R) based on their insulin-sensitivity index, the M value, determined by the hyperinsulinemic euglycemic clamp technique. In the second study, we determined FABP4 levels in 30 young NT men with or without a family history of hypertension (FH+ and FH-, respectively; n = 15 each). RESULTS Serum FABP4 level was significantly higher in the EHT-R than in the NT, whereas elevation of FABP4 level in the EHT-S was not statistically significant. FABP4 level was positively correlated with age, body mass index (BMI), blood pressure, and triglycerides and negatively correlated with the M value. FABP4 level was an independent predictor of mean arterial pressure after adjustment of age, gender, and adiposity. The FH+ group had a significantly lower level of M value and higher level of FABP4 than did the FH(-)group, and FABP4 concentration was an independent determinant of the M value. CONCLUSIONS FABP4 contributes to blood pressure elevation and atherogenic metabolic phenotype in hypertensives, and the elevation of FABP4 is predisposed by a family history of hypertension.
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