期刊
NATURE REVIEWS IMMUNOLOGY
卷 8, 期 11, 页码 837-848出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nri2423
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资金
- National Institutes of Health (NIH) [AI033443, AI066109, AI059440, AI068977]
- NIH National Institute of General Medical Science (NIGMS) Medical Scientist Training Program (MSTP) [GM07205]
Research on the biological function of nuclear factor-kappa B (NF-kappa B), a key mediator of inducible transcription in the immune system, has traditionally focused on its role in the initiation of innate and adaptive immune responses. These studies have largely concentrated on the mechanisms of signalling that lead to NF-kappa B activation and on the positive role of NF-kappa B in both physiological immunity and pathological inflammation. More recently, there has been growing interest in the mechanisms that directly regulate the NF-kappa B transcriptional programmes. As a result, several new NF-kappa B regulatory components have been identified and some of the known components have been assigned new roles. In this Review, we discuss these new insights into the regulation of NF-kappa B.
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