期刊
AMERICAN JOURNAL ON MENTAL RETARDATION
卷 113, 期 6, 页码 427-438出版社
AMER ASSOC MENTAL RETARDATION
DOI: 10.1352/2008.113:427-438
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资金
- NICHD NIH HHS [HD036071, R01 HD036071, R01 HD036071-10, P30 HD002274, HD02274] Funding Source: Medline
- Autism Speaks [AS1751] Funding Source: Medline
Autism, which is common in individuals with fragile X syndrome, is often difficult to diagnose. We compared the diagnostic classifications of two measures for autism diagnosis, the ADOS and the ADI-R, in addition to the DSM-IV-TR in 63 males with this syndrome. Overall, 30% of the subjects met criteria for autistic disorder and 30% met criteria for PDD-NOS. The classifications on the ADOS and DSM-IV-TR were most similar, whereas the ADI-R classified subjects as autistic much more frequently. We further investigated the relationship of both FMRP and FMR1 mRNA to symptoms of autism in this cohort and found no significant relationship between the measures of autism and molecular features, including FMRP, FMR1 mRNA, and CGG repeat number.
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