期刊
AMERICAN JOURNAL OF HYPERTENSION
卷 22, 期 10, 页码 1120-1125出版社
OXFORD UNIV PRESS
DOI: 10.1038/ajh.2009.149
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资金
- NHLBI NIH HHS [F32 HL078147-03, F32 HL078147, P01 HL051971-150002, P01 HL051971] Funding Source: Medline
BACKGROUND Inflammatory cytokines such as tumor necrosis factor-alpha (TNF-alpha) may be an important link between placental ischemia and hypertension in preeclampsia. We examined the effect of 17-hydroxyprogesterone caproate (17-OHP) on TNF-alpha-stimulated endothelin (ET) production and hypertension during pregnancy. METHODS TNF-alpha-stimulated ET was examined from endothelial cells cultured in the presence and absence of progesterone. Blood pressure and tissue ET-1 were measured in the following groups of pregnant rats: controls, 17-OHP (332 mg/kg),TNF-alpha treated (50 ng/day),TNF-alpha treated+17-OHP. RESULTS Progesterone abolished TNF-alpha-stimulated ET-1 from endothelial cells. TNF-alpha-induced hypertension was associated with significant increases in renal and placental ET-1. Administration of 17-OHP attenuated TNF-alpha-induced hypertension and decreased renal ET-1. CONCLUSION Progesterone directly abolished TNF-alpha-stimulated ET-1 and attenuated TNF-alpha-induced hypertension, possibly via suppression of the renal ET-1 system. These data suggest that treatment with progesterone of hypertension associated with elevated cytokines during pregnancy may be worthy of further consideration.
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