期刊
AMERICAN JOURNAL OF HUMAN GENETICS
卷 93, 期 1, 页码 150-157出版社
CELL PRESS
DOI: 10.1016/j.ajhg.2013.05.023
关键词
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资金
- Research Council of Norway
- University of Bergen
- K.G. Jebsen Foundation
- Helse Vest
- Innovest
- European Research Council
- Nils Normans Foundation
- National Institutes of Health [DK55545]
The phosphatidylinositol 3 kinase (PI3K) pathway regulates fundamental cellular processes such as metabolism, proliferation, and survival. A central component in this pathway is the p85 alpha, regulatory subunit, encoded by PIK3R1. Using whole-exome sequencing, we identified a heterozygous PIK3R1 mutation (c.1945C>T [p.Arg649Trp]) in two unrelated families affected by partial lipodystrophy, low body mass index, short stature, progeroid face, and Rieger anomaly (SHORT syndrome). This mutation led to impaired interaction between p85 alpha and IRS-1 and reduced AKT-mediated insulin signaling in fibroblasts from affected subjects and in reconstituted Pik3r1-knockout preadipocytes. Normal PI3K activity is critical for adipose differentiation and insulin signaling; the mutated PIK3R1 therefore provides a unique link among lipodystrophy, growth, and insulin signaling.
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