期刊
AMERICAN JOURNAL OF HUMAN GENETICS
卷 89, 期 3, 页码 446-450出版社
CELL PRESS
DOI: 10.1016/j.ajhg.2011.08.001
关键词
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资金
- Astra Zeneca UK
- MRC [G0100594, G0901461, MC_U122886349] Funding Source: UKRI
- Medical Research Council [G0901461, G0100594, MC_U122886349] Funding Source: researchfish
Osteoarthritis (OA) is a prevalent, heritable degenerative joint disease with a substantial public health impact. We used a 1000-Genomes-Project-based imputation in a genome-wide association scan for osteoarthritis (3177 OA cases and 4894 controls) to detect a previously unidentified risk locus. We discovered a small disease-associated set of variants on chromosome 13. Through large-scale replication, we establish a robust association with SNPs in MCF2L (rs11842874, combined odds ratio [95% confidence interval] 1.17 [1.11-1.23], p = 2.1 x 10(-8)) across a total of 19,041 OA cases and 24,504 controls of European descent. This risk locus represents the third established signal for OA overall. MCF2L regulates a nerve growth factor (NGF), and treatment with a humanized monoclonal antibody against NGF is associated with reduction in pain and improvement in function for knee OA patients.
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