期刊
AMERICAN JOURNAL OF HUMAN GENETICS
卷 86, 期 1, 页码 34-44出版社
CELL PRESS
DOI: 10.1016/j.ajhg.2009.12.002
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资金
- NHGRI NIH HHS [P50HG02351, P50 HG002351] Funding Source: Medline
- NIGMS NIH HHS [1R01GM076036-01, R01 GM076036] Funding Source: Medline
It is well known that average levels of population structure are higher oil the X chromosome compared to autosomes in humans. However, there have been surprisingly few analyses oil the spatial distribution of population structure along the X chromosome. With publicly available data from the HapMap Project and Perlegen Sciences, we show a strikingly Punctuated pattern of X chromosome population structure. Specifically, 87% of X-linked HapMap SNPs within the top 1% of F-ST values cluster into five distinct loci. The largest of these regions spans 5.4 Mb and contains 66% of the most highly differentiated HapMap SNPs on the X chromosome. We demonstrate that the extreme clustering of highly differentiated SNPs on the X chromosome is not an artifact of ascertainment bias, nor is it specific to the populations genotyped in the HapMap Project. Rather, additional analyses and resequencing data suggest that these five regions have been substrates of recent and strong adaptive evolution. Finally, we discuss the implications that patterns of X-linked Population structure have on the evolutionary history 7 of African populations.
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