Quantitative measurements and ana- lysis in electrodiagnostic studies: present and future

Electrodiagnostic studies (nerve conduction and needle electromyography) are powerful methods to study diseases of nerves and muscles. Conduction studies are performed to assess the continuity, anatomic course, excitability, number of axons and their synaptic connections, while needle electromyography examination is performed to assess the 'electrical stability' of the muscle fiber membrane, and the study of motor units (architecture, activation and number). We have reviewed the relationship between the quantitative measurements and the generators of the recorded potentials. Based on these relationships, the expected patterns of abnormalities for different pathologies are tabulated. This gives us a better appreciation of the sensitivity, specificity and usefulness of different tests when planning and conducting an electrodiagnostic examination. The limitations of current methods are indicated to suggest the need for future development.