期刊
FEMS MICROBIOLOGY REVIEWS
卷 32, 期 6, 页码 1010-1032出版社
OXFORD UNIV PRESS
DOI: 10.1111/j.1574-6976.2008.00131.x
关键词
G protein-coupled receptor; G protein; extracellular sensing; fungus
类别
资金
- NIAID NIH HHS [R01 AI050113, R01 AI039115-11, R01 AI039115, R21 AI070230-01A1, R01 AI039115-12, R21 AI070230-02, R01 AI039115-10, R21 AI070230] Funding Source: Medline
G protein-coupled receptors (GPCRs) represent the largest family of transmembrane receptors and are responsible for transducing extracellular signals into intracellular responses that involve complex intracellular-signaling networks. This review highlights recent research advances in fungal GPCRs, including classification, extracellular sensing, and G protein-signaling regulation. The involvement of GPCRs in pheromone and nutrient sensing has been studied extensively over the past decade. Following recent advances in fungal genome sequencing projects, a panoply of GPCR candidates has been revealed and some have been documented to play key roles sensing diverse extracellular signals, such as pheromones, sugars, amino acids, nitrogen sources, and even photons. Identification and deorphanization of additional putative GPCRs may require the development of new research tools. Here, we compare research on GPCRs in fungi with information derived from mammalian systems to provide a useful road map on how to better understand ligand-GPCR-G protein interactions in general. We also emphasize the utility of yeast as a discovery tool for systemic studies of GPCRs from other organisms.
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