期刊
ONCOLOGY REPORTS
卷 20, 期 5, 页码 1099-1103出版社
SPANDIDOS PUBL LTD
DOI: 10.3892/or_00000115
关键词
fucoxanthin; bladder cancer cell; antiproliferative effect; apoptosis; caspase-3 activity
类别
Bladder cancer is a common but serious malignancy. It is widely accepted that chemoprevention may be an effective way to decrease the rate of recurrence and morbidity. We first determined antigrowth and apoptosis-induction activity of fucoxanthin from dietary Laminaria japonica against EJ-1 human bladder cancers. Fucoxanthin significantly reduced the cell viability in a dose- and time-dependent manner. The induction of apoptosis in EJ-1 cells was characterized by morphological changes, DNA ladder, and increased percentage of hypodiploid cells, activating caspase-3 activity. The ratio of apoptotic cells reached > 93% after treatment for 72 h with 20 mu M fucoxanthin. The findings obtained indicate that fucoxanthin may act as a chemopreventive and/or chemotherapeutic carotenoid in bladder cancer cells by modulating cell viability.
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