期刊
AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY
卷 19, 期 1, 页码 64-71出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/JGP.0b013e3181df4498
关键词
Coping; personal control; cardiovascular disease; inflammation; elderly
资金
- National Institute on Aging [AG 015301, AG 031090]
- NATIONAL INSTITUTE ON AGING [RF1AG015301, R01AG031090, R01AG015301, R01AG008415] Funding Source: NIH RePORTER
Objective: The proinflammatory cytokine interleukin (IL)-6 has been linked with health morbidity, particularly risk for cardiovascular disease (CVD). The purpose of this study was to investigate the potential protective role of coping self-efficacy on the relationship between caregiving stress and circulating concentrations of IL-6. Methods: A total of 62 elderly caregivers of patients with Alzheimer's disease (mean age: 74 years) were assessed for plasma concentrations of IL-6, caregiving-related overload, and coping self-efficacy. Multiple regression was used to examine the main effects of stress and self-efficacy, as well as the interaction between stress and self-efficacy, in predicting plasma IL-6 after controlling for age, gender, resting blood pressure, and obesity. Results: There was a significant interaction between stress and self-efficacy in predicting IL-6. Post-hoc examination indicated that when self-efficacy was low, stress was significantly related to IL-6 (beta = 0.43). However, when self-efficacy was high, stress was not significantly related to IL-6 (beta = -0.10). Conclusion: Caregiving stress in combination with low coping self-efficacy is significantly related to IL-6, a known risk marker for health morbidity, particularly CVD. However, stress was not associated with IL-6 with high self-efficacy. Although limited and preliminary, these results point to a potential protective effect of self-efficacy on caregiver health that can be tested in longitudinal studies. (Am J Geriatr Psychiatry 2010; 19: 64-71)
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