期刊
AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY
卷 17, 期 8, 页码 716-721出版社
ELSEVIER SCIENCE INC
DOI: 10.1097/JGP.0b013e3181aad5d7
关键词
Depression; metabolic syndrome; cortisol
资金
- NHLBI NIH HHS [R01 HL72972-01] Funding Source: Medline
Objectives: High-cortisol levels in depressed persons could possibly give rise to the metabolic syndrome. This study investigated cross-sectionally whether depression and high-cortisol levels increased the odds of metabolic syndrome in an older community-based sample. Methods: In 1,212 participants, aged >= 65 years, enrolled in the Longitudinal Aging Study Amsterdam, depression (major [1-month diagnosis] or subthreshold [no 1-month diagnosis, but symptoms]), metabolic syndrome (modified Adult Treatment Panel III criteria), and free cortisol index (total serum cortisol/cortisol binding globulin) were assessed. Results: Major depression was not associated with the metabolic syndrome (odds ratio [OR] = 1.16, 95% confidence interval [CI] = 0.54-2.49), but subthreshold depression was associated with a decreased odds (OR = 0.55, 95% CI = 0.37-0.82). Persons with higher levels of free cortisol index showed a higher odds of metabolic syndrome (OR per standard deviation increase = 1.21, 95% CI = 1.06-1.39). Conclusions: As persons with high-cortisol levels more often had metabolic syndrome, hypercortisolemia within depressed persons may increase the risk of metabolic syndrome. (Am J Geriatr Psychiatry 2009; 17: 716-721)
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