期刊
AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY
卷 16, 期 4, 页码 272-282出版社
ELSEVIER SCIENCE INC
DOI: 10.1097/JGP.0b013e3181602a2b
关键词
working memory; postmenopausal women; fMRI; cholinergic system
资金
- NCI NIH HHS [R01 CA101318, R01 CA101318-05] Funding Source: Medline
- NIA NIH HHS [R01 AG019771-06, R01-AG021476, R01 AG019771, R01 AG021476, R01-AG19771, F32 AG023430] Funding Source: Medline
- PHS HHS [NCRR-00109] Funding Source: Medline
Objectives: An important aspect of furthering our understanding of the central nervous system function after menopause is to examine the cerebral circuitry that appears to be influenced by cholinergic antagonist drugs in the presence and absence of estrogen. This pilot study investigated the effects of two anticholinergic drugs on brain activation and working memory performance in postmenopausal women not taking estrogen. This approach simulates the effects of age- or disease-related neuroreceptor or neuronal loss by temporarily blocking pre- and postsynaptic muscarinic and nicotinic cholinergic receptors. Design: Six healthy postmenopausal women took part in three drug challenges using the antinicotinic drug mecamylamine (MECA, 20 mg, oral), the antimuscarinic drug scopolamine (SCOP, 2.5 mu g/kg, IV), and placebo during functional magnetic resonance imaging. The cognitive measure was a visually presented verbal N-back test of working memory. Results: Neither MECA nor SCOP significantly impaired performance on the verbal N-back. Functional magnetic resonance imaging results showed greater increases in frontal lobe activation in the placebo condition relative to each drug condition with different specific regional activation for MECA and SCOP. Conclusions: These preliminary results suggest that brain activation patterns are sensitive to cholinergic modulation in postmenopausal women and that differential effects may be observed following nicotinic versus muscarinic blockade. This approach offers a potentially valuable method for modeling age-related changes in brain function, and the findings may have implications for cholinergic contributions to normal and pathologic aging.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据