期刊
INFANT BEHAVIOR & DEVELOPMENT
卷 31, 期 4, 页码 590-593出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.infbeh.2008.07.007
关键词
Prenatal dopamine; Depression
资金
- NCCIH NIH HHS [AT 00370, K05 AT001585, R01 AT000370-06, K05 AT001585-03, AT 001585, R01 AT000370] Funding Source: Medline
- NIMH NIH HHS [R37 MH046586-11, MH 46586, K05 MH000331-21, MH 0033 1] Funding Source: Medline
Depressed pregnant women (N=126) were divided into high and low prenatal maternal dopamine (HVA) groups based on a tertile split on their dopamine levels at 20 weeks gestation. The high versus the low dopamine group had lower Center for Epidemiological Studies-Depression Scale (CES-D) scores, higher norepinephrine levels at the 20-week gestational age visit and higher dopamine and serotonin levels at both the 20- and the 32-week gestational age visits. The neonates of the mothers with high versus low prenatal dopamine levels also had higher dopamine and serotonin levels as well as lower cortisol levels. Finally, the neonates in the high dopamine group had better autonomic stability and excitability scores on the Brazelton Neonatal Behavior Assessment Scale. Thus, prenatal maternal dopamine levels appear to be negatively related to prenatal depression scores and positively related to neonatal dopamine and behavioral regulation, although these effects are confounded by elevated serotonin levels. (C) 2008 Elsevier Inc. All rights reserved.
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