期刊
AMERICAN JOURNAL OF GASTROENTEROLOGY
卷 108, 期 4, 页码 594-601出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1038/ajg.2012.471
关键词
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资金
- NIH [U54-LM008748, K08 AR060257, K24 AR052403, P60 AR047782, R01 AR049880]
- American Gastroenterological Association
- US National Institutes of Health [K23 DK097142]
- Katherine Swan Ginsburg Fund
- US National Institutes of Health (NIH) [R01-AR056768, U01-GM092691, R01-AR059648]
- Burroughs Wellcome Fund
OBJECTIVES: Psychiatric comorbidity is common in Crohn's disease (CD) and ulcerative colitis (UC). Inflammatory bowel disease (IBD)-related surgery or hospitalizations represent major events in the natural history of the disease. The objective of this study is to examine whether there is a difference in the risk of psychiatric comorbidity following surgery in CD and UC. METHODS: We used a multi-institution cohort of IBD patients without a diagnosis code for anxiety or depression preceding their IBD-related surgery or hospitalization. Demographic-, disease-, and treatment-related variables were retrieved. Multivariate logistic regression analysis was performed to individually identify risk factors for depression and anxiety. RESULTS: Our study included a total of 707 CD and 530 UC patients who underwent bowel resection surgery and did not have depression before surgery. The risk of depression 5 years after surgery was 16% and 11% in CD and UC patients, respectively. We found no difference in the risk of depression following surgery in the CD and UC patients (adjusted odds ratio, 1.11; 95% confidence interval, 0.84-1.47). Female gender, comorbidity, immunosuppressant use, perianal disease, stoma surgery, and early surgery within 3 years of care predicted depression after CD surgery; only the female gender and comorbidity predicted depression in UC patients. Only 12% of the CD cohort had >= 4 risk factors for depression, but among them nearly 44% subsequently received a diagnosis code for depression. CONCLUSIONS: IBD-related surgery or hospitalization is associated with a significant risk for depression and anxiety, with a similar magnitude of risk in both diseases.
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