期刊
FUTURE LIPIDOLOGY
卷 3, 期 6, 页码 637-649出版社
FUTURE MEDICINE LTD
DOI: 10.2217/17460875.3.6.637
关键词
atherosclerosis; inflammation; metabolic syndrome; obesity; oxidative stress; oxidized LDL
资金
- NHLBI NIH HHS [R01 HL053560-12, R01 HL053560] Funding Source: Medline
The metabolic syndrome is a common and complex disorder combining obesity, dyslipidemia, hypertension and insulin resistance. It is associated with a high cardiovascular risk that can only partially be explained by its components. There is evidence that low-grade inflammation and high oxidative stress add to this risk. Oxidized LDL, a marker of lipoprotein-associated oxidative stress, is an emerging cardiovascular risk factor. In this review, we demonstrate that the metabolic syndrome exacerbates oxidized LDL in a feedback loop, We introduce molecular mechanisms underlying this loop. Finally, we demonstrate that weight loss and statin treatment lower metabolic syndrome factors associated with a reduction of oxidized LDL. The current data warrant further investigation into the role of lifestyle and therapeutic interventions that inhibit tissue-associated oxidation of LDL in the prevention of the metabolic syndrome.
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