期刊
INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY
卷 59, 期 7-9, 页码 399-406出版社
UNIV BASQUE COUNTRY UPV-EHU PRESS
DOI: 10.1387/ijdb.150232dg
关键词
TRP channel cancer expression screening
资金
- Ministere de l'Education Nationale
- Institut National de la Sante et de la Recherche Medicale (INSERM)
- Institut National du Cancer [INCa-7952]
- Fondation ARC pour la recherche sur le cancer [PJA 20141202010]
- Association pour la Recherche sur les Tumeurs de la Prostate (ARTP)
- Vinci program -Universite Franco-Italienne
Despite the intensive research of the last three decades into Transient Receptor Potential (TRP) cation channels, no precise and complete profiling of these channels is yet available regarding their involvement in physiopathology and carcinogenesis in particular. TRP channel activity is crucial for all the essential hallmarks of carcinogenesis such as proliferation, apoptosis, migration and angiogenesis, which is the reason why these channels have been proposed not only as clinical markers, but also as promising targets for anti-cancer therapy. However, in the majority of studies, each channel has been considered as a separate molecular entity and studied independently from the other TRPs, while a complete transportome of the specific stages of carcinogenesis is required for the effective use of these targets. This review focuses on the partial TRP expression profiles found in the literature and the means by which a full TRP signature could be achieved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据