期刊
INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY
卷 59, 期 10-12, 页码 511-517出版社
UNIV BASQUE COUNTRY UPV-EHU PRESS
DOI: 10.1387/ijdb.150178xh
关键词
N-myc downstream regulated gene (Ndrg) family; Xenopus tropicalis; expression pattern; embryogenesis
资金
- National Basic Research Program of China [2012CB967902]
- National Natural Science Foundation of China [31271560, 30871419, 31301148]
The N-myc downstream regulated gene (Ndrg) family consists of four main members Ndrg1,2,3, and 4. The Ndrggenes are involved in many vital biological events including development. However, comprehensive expression patterns of this gene family during vertebrate embryogenesis remain largely unknown. Here, we analyzed the Ndrg family from the evolutionary perspective and examined the expression patterns of the Ndrg genes during Xenopus tropicalis embryogenesis. Different Ndrg family members of vertebrates are separated into different homology clusters which can be further classified into two groups and each Ndrg family member is well conserved during evolution. The temporal and spatial expression patterns of Ndrg1,2,3and 4 are different during early Xenopus tropicalis development. Ndrg1, 2 and 4 are maternally expressed genes while Ndrg3 is a zygotically expressed gene. The Ndrg genes are differentially expressed in the developing central nervous system, the developing sensory organs, and the developing excretory organs. Moreover, they also show other specific expression domains. Our results indicate that the Ndrg genes exhibit specific expression patterns and may play different roles during vertebrate embryogenesis.
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