期刊
INTERNATIONAL JOURNAL OF DERMATOLOGY
卷 54, 期 8, 页码 880-888出版社
WILEY
DOI: 10.1111/ijd.12883
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T-helper 22 (Th22) cell is a new subset of CD4(+) T cells that secrets interleukin (IL)-22 but not IL-17 or interferon-. Th22 is distinct from Th17 and other known CD4(+) T-cell subsets with distinguished gene expression and function. Th22 subsets have chemokine receptors CCR6(+) CCR4(+) CCR10(+) phenotype and aryl hydrocarbon receptor as the key transcription factor. This T-helper subset, by producing cytokines such as IL-22, IL-13, and tumor necrosis factor-, is implicated in the pathogenesis of inflammatory skin disorder. This review discusses the role of Th22 and its cytokine IL-22 in the immunopathogenesis of inflammatory skin disorders such as psoriasis and atopic dermatitis.
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