期刊
AMERICAN JOURNAL OF EPIDEMIOLOGY
卷 188, 期 1, 页码 250-257出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/aje/kwy201
关键词
causal inference; clinical equipoise; epidemiologic methods; inverse probability weighting; overlap weighting; statistical efficiency; trimming
资金
- Agency for Healthcare Research and Quality [R03 HS24310]
- National Science Foundation [SES-1424688]
The popular inverse probability weighting method in causal inference is often hampered by extreme propensity scores, resulting in biased estimates and excessive variance. A common remedy is to trim patients with extreme scores (i.e., remove them from the weighted analysis). However, such methods are often sensitive to the choice of cutoff points and discard a large proportion of the sample. The implications for bias and the precision of the treatment effect estimate are unclear. These problems are mitigated by a newly developed method, the overlap weighting method. Overlap weights emphasize the target population with the most overlap in observed characteristics between treatments, by continuously down-weighting the units in the tails of the propensity score distribution. Here we use simulations to compare overlap weights to standard inverse probability weighting with trimming, in terms of bias, variance, and 95% confidence interval coverage. A range of propensity score distributions are considered, including settings with substantial nonoverlap and extreme values. To facilitate practical implementation, we further provide a consistent estimator for the standard error of the treatment effect estimated using overlap weighting.
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