期刊
AMERICAN JOURNAL OF EPIDEMIOLOGY
卷 179, 期 8, 页码 974-986出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/aje/kwu006
关键词
flavonoids; proanthocyanidins; prospective cohort study; prostate cancer
资金
- US Department of Agriculture, Agricultural Research Service [58-1950-7-707]
- American Cancer Society
Higher dietary intakes of flavonoids and proanthocyanidins have been associated with a lower risk of several cancers. Few prospective epidemiologic studies have examined individual flavonoids and proanthocyanidins in relation to prostate cancer. We examined these associations in a prospective US cohort of 43,268 men with a mean age of 70 years who completed detailed self-administered questionnaires in 19992000. During a mean follow-up of 7.8 years, 3,974 total prostate cancers, including 567 high-grade cases and 362 advanced cases, were ascertained. Cox proportional hazards regression models were used to calculate multivariable-adjusted relative risks and 95 confidence intervals. Residual energy-adjusted total flavonoids (for fifth quintile vs. first quintile, relative risk 1.11, 95 confidence interval: 1.01, 1.23; P for trend 0.02) and several subclasses were positively associated with overall prostate cancer risk, mostly limited to the top quintile and the first 2 years of follow-up. The associations for total flavonoids, flavan-3-ols, and proanthocyanidins with high-grade prostate cancer risk varied by follow-up time. During follow-up from 2002 to 2009, we observed suggestive inverse trends with higher total flavonoids (P for trend 0.05) and proanthocyanidins (P for trend 0.04) with high-grade prostate cancer, but not with advanced prostate cancer. Although evidence is limited, a possible role of total flavonoids and proanthocyanidins in prostate cancer tumor progression deserves further study.
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