期刊
AMERICAN JOURNAL OF EPIDEMIOLOGY
卷 176, 期 4, 页码 289-298出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/aje/kws004
关键词
aging; alcohol drinking; macular degeneration
资金
- VicHealth
- Cancer Council Victoria
- National Health and Medical Research Council of Australia (NHMRC) [209057, 251533, 396414]
- Ophthalmic Research Institute of Australia
- American Health Assistance Foundation
- John Reid Charitable Trust
- Perpetual Trustees
- Royal Victorian Eye and Ear Hospital
- NHMRC
- Wagstaff Fellowship
- Hugh Noel Puckle Scholarship
Little evidence exists regarding associations between age-related macular degeneration (AMD) and moderate alcohol consumption, patterns of consumption, or different types of alcoholic beverage. The authors examined associations between AMD prevalence and alcohol intake using 20,963 participants from the Melbourne Collaborative Cohort Study aged 4069 years at baseline (19901994). Participants alcohol consumption was determined from a structured interview at baseline. At follow-up from 2003 to 2007, digital macula photographs of both eyes were taken and evaluated for early and late AMD signs. Drinking more than 20 g of alcohol per day was associated with an approximate 20 increase in the odds of early AMD (odds ratio 1.21, 95 confidence interval: 1.06, 1.38; P 0.004) when compared with those who reported no alcohol intake at baseline, having adjusted for sex, age, smoking, country of birth, education, physical activity, and energy from food. This positive association was apparent for wine, beer, and spirits. The estimates were similar for both sexes. The odds ratio for those drinking more than 20 g of alcohol per day for late AMD was 1.44 (95 confidence interval: 0.85, 2.45; P 0.17). These results show a modest association between alcohol consumption and increased AMD risk.
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