期刊
AMERICAN JOURNAL OF EPIDEMIOLOGY
卷 176, 期 11, 页码 970-978出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/aje/kws263
关键词
allergy; immunology; leukemia
资金
- National Science Council of Taiwan [NSC 99-2314-B-400-004]
- Department of Health, Taiwan [DOH101-TD-C-111-004]
- Leukemia and Lymphoma Society of America [6026-10]
A deficit of normal immune stimulation in early childhood is a suspected risk factor for both childhood acute lymphoblastic leukemia (ALL) and allergies. The present study utilized a population-based case-control design using medical claims data from the National Health Insurance Research Database of Taiwan to evaluate the association between allergy and childhood leukemia. Eight hundred forty-six childhood ALL patients who were newly diagnosed during 2000 to 2008 and were older than 1 but less than 10 years of age were individually matched with 3,374 controls based on sex, birth date, and time of diagnosis (reference date for the controls). Conditional logistic regression was performed to assess the association between childhood ALL and allergies. An increased risk of ALL was observed with having an allergy less than 1 year before the cases ALL diagnosis (odds ratio (OR) 1.7, 95 confidence interval (CI): 1.5, 2.0), more than 1 year before the cases diagnosis (OR 1.3, 95 CI: 1.1, 1.5), and before the age of 1 year (OR 1.4, 95 CI: 1.1, 1.7). These results suggest that the pathogenesis of childhood ALL and allergy share a common biologic mechanism.
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