期刊
AMERICAN JOURNAL OF EPIDEMIOLOGY
卷 174, 期 6, 页码 642-651出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/aje/kwr123
关键词
birth weight; body mass index; breast neoplasms; child; growth; insulin-like growth factor 1; insulin-like growth factor binding protein 3; obesity
资金
- National Cancer Institute [R03 CA132182, T32 CA009001, P01 CA87969, R01 CA50385, U01 CA49449, R01 CA67262]
Body size in early life has been associated with breast cancer risk. This may be partly mediated through the insulin-like growth factor (IGF) pathway. The authors assessed whether birth weight, body fatness at ages 5 and 10 years, and body mass index (BMI; weight (kg)/height (m)(2)) at age 18 years were associated with plasma concentrations of insulin-like growth factor 1 (IGF-1) and insulin-like growth factor binding protein 3 in 6,520 women aged 32-70 years at blood draw from the Nurses' Health Study (1990-2006) and Nurses' Health Study II (1997-2005). Birth weight, body fatness in childhood, and BMI at age 18 years were inversely associated with adult IGF-1 levels. For example, IGF-1 levels were 11.9% lower in women who reported being heaviest at age 10 years than in those who were leanest at age 10 (P-trend < 0.0001). Further, women who reported their birth weight as >= 10 pounds (>= 4.5 kg) (vs. < 5.5 pounds (< 2.5 kg)) had 7.9% lower IGF-1 levels (P-trend = 0.002). Women whose BMI at age 18 years was >= 30 (vs. < 20) had 14.1% lower IGF-1 levels (P-trend < 0.0001). Similar inverse associations were observed for insulin-like growth factor binding protein 3. These observations did not vary by adult BMI or menopausal status at blood draw. These findings suggest that altered IGF-1 levels in adulthood may be a mechanism through which early-life body size influences subsequent breast cancer risk.
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