期刊
AMERICAN JOURNAL OF EPIDEMIOLOGY
卷 167, 期 8, 页码 954-961出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/aje/kwm395
关键词
cerebral infarction; diet; folic acid; methionine; stroke; vitamin B 6; vitamin B 12
资金
- NCI NIH HHS [N01-CN-45165] Funding Source: Medline
- CCR NIH HHS [N01-RC-37004, N01-RC-45035] Funding Source: Medline
The associations of dietary folate, vitamin B-6, vitamin B-12, and methionine intakes with risk of stroke subtypes were examined among 26,556 male Finnish smokers, aged 50-69 years, enrolled in the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study. Dietary intake was assessed at baseline by using a validated food frequency questionnaire. During a mean follow-up of 13.6 years, from 1985 through 2004, 2,702 cerebral infarctions, 383 intracerebral hemorrhages, and 196 subarachnoid hemorrhages were identified from national registers. In analyses adjusting for age and cardiovascular risk factors, a high folate intake was associated with a statistically significant lower risk of cerebral infarction but not intracerebral or subarachnoid hemorrhages. The multivariate relative risk of cerebral infarction was 0.80 (95% confidence interval: 0.70, 0.91; p(trend) = 0.001) for men in the highest versus lowest quintile of folate intake. Vitamin B-6, vitamin B-12, and methionine intakes were not significantly associated with any subtype of stroke. These findings in men suggest that a high dietary folate intake may reduce the risk of cerebral infarction.
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