期刊
AMERICAN JOURNAL OF EPIDEMIOLOGY
卷 167, 期 11, 页码 1365-1374出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/aje/kwn060
关键词
Asian continental ancestry group; body mass index; diabetes mellitus; ethnic groups; hypertension
资金
- NCRR NIH HHS [M01 RR000046] Funding Source: Medline
- NHLBI NIH HHS [N01HC55021, N01HC55020, N01HC55022, N01-HV-59224, N01-HV-08112, N01-HC-55021, N01-HC-55018, N01HC55016, N01HC55019, N01 HC055015, N01-HC-55015, N01-HC-55019, N01-HC-55016, N01-HV-12243, N01HC55015, N01-HC-55020, N01-HC-55022, N01HC55018] Funding Source: Medline
- NIDDK NIH HHS [R01 DK069678] Funding Source: Medline
- DIVISION OF EPIDEMIOLOGY AND CLINICAL APPLICATIONS [N01HC055016, N01HC055022, N01HC055021, N01HC055018, N01HC055020, N01HC055019, N01HC055015] Funding Source: NIH RePORTER
- DIVISION OF HEART AND VASCULAR DISEASES [N01HV012243, N01HV008112, N01HV059224] Funding Source: NIH RePORTER
- NATIONAL CENTER FOR RESEARCH RESOURCES [M01RR000046] Funding Source: NIH RePORTER
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [R42HL055018, R41HL055019, R41HL055018] Funding Source: NIH RePORTER
Researchers have hypothesized that the impact of body mass index on chronic disease may be greater in Asians than in Whites; however, most studies are cross-sectional and have no White comparison group. The authors compared the associations with body mass index in Chinese Asians (n = 5,980), American Whites (n = 10,776), and American Blacks (n = 3,582) using prospective data from the People's Republic of China Study (1983-1994) and the Atherosclerosis Risk in Communities Study (1987-1998). Slopes of risk differences over body mass index levels were compared among the three ethnic groups in adjusted analyses. The authors found larger associations with body mass index in Chinese Asians compared with American Whites and Blacks for hypertension (p < 0.05). The increase in the incidence of hypertension associated with a one-unit increase in body mass index over approximately 8 years of follow-up was 2.5, 1.7, and 1.8 percentage points for Chinese Asians, American Whites, and American Blacks, respectively. For diabetes, the estimates were 1.7, 1.1, and 1.6 percentage points for the same groups- higher in Chinese Asians than in American Whites (p < 0.05) but similar between Chinese Asians and American Blacks. Given the ethnic differences in associations, the results support advocacy of public health and medical actions toward obesity prevention and treatment in China.
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