期刊
INTERNATIONAL JOURNAL OF DENTISTRY
卷 2009, 期 -, 页码 -出版社
HINDAWI LTD
DOI: 10.1155/2009/280737
关键词
-
资金
- Ministry of Education, Culture, Sports, Science, and Technology of Japan [17592186, 20592461]
- Grants-in-Aid for Scientific Research [20592461, 21390560, 17592186] Funding Source: KAKEN
Background. Recent reports have found a positive relationship between periodontitis and the hormones cortisol and dehydroepiandrosterone (DHEA). We investigated the associations between those levels and periodontitis in never-smokers and smokers of elderly subjects. Subjects and Methods. Cortisol and DHEA levels in saliva were determined in 171 subjects (85 males, 86 females), with clinical examinations including probing depth (PD) and clinical attachment loss (CAL) also performed. Results. Smoking had effects on cortisol and DHEA levels, and those were significantly associated with severe PD and CAL in never-smokers. According to ROC analysis, the cutoff values of cortisol and DHEA to obtain the optimal sensitivity and specificity for detecting severe periodontitis were 2.06 ng/mL and 60.24 pg/mL, respectively, for PD, and 2.12 ng/mL and 61.78 pg/mL, respectively, for CAL. Conclusions. Assessment of hormone levels may be a useful screening method for periodontitis, though limited to never-smokers. Copyright (C) 2009 Toshihiro Ansai et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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