期刊
AMERICAN JOURNAL OF DERMATOPATHOLOGY
卷 35, 期 2, 页码 159-166出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/DAD.0b013e31825c3a33
关键词
cutaneous small- to medium-sized pleomorphic T-cell lymphoma; primary cutaneous aggressive epidermotropic CD8+cytotoxic T-cell lymphoma; cutaneous peripheral T-cell lymphoma not otherwise specified; cytotoxic lymphoma; extrafacial; pseudolymphoma
类别
Three cases with CD8+ small- to medium-sized lymphoproliferations in the skin at extrafacial sites are described. Clinically, the patients presented with papulonodular or plaque-like lesions without preceding patches. Histopathologically, nonepidermotropic nodular or diffuse infiltrates were composed of small-to medium-sized pleomorphic lymphocytes, which expressed CD8 (more than 80% of the cells) and granzyme B (60%-70% of the cells), but were negative for CD4, CD30, and CD56. There was no association with Epstein-Barr virus. A clonal T-cell population was detected in 2 patients. Staging examinations did not reveal extracutaneous involvement. The 2 patients with solitary lesions underwent complete remission after radiation therapy, whereas 1 patient developed multifocal lesions and several recurrences. These CD8+ small-to medium-sized lymphoproliferations of the skin at extrafacial sites may belong to a spectrum of phenotypically and prognostically heterogeneous cutaneous small-to medium-sized lymphoid proliferations, which are characterized by an indolent course in most patients.
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