期刊
AMERICAN JOURNAL OF CLINICAL PATHOLOGY
卷 138, 期 5, 页码 652-656出版社
OXFORD UNIV PRESS INC
DOI: 10.1309/AJCP00INMGIFYFNQ
关键词
Immunocytochemistry; CINtec PLUS; Cervix; Glandular lesions; AIS
类别
资金
- Fondazione Banco di Sardegna, Cagliari, Italy
Cytologic findings of glandular lesions of the cervix uteri are often difficult to evaluate. We studied the usefulness of CINtec PLUS p16/Ki-67 double stain (mtm laboratories, Heidelberg, Germany) for the diagnosis of glandular lesions. The study included 47 abnormal results on liquid-based cytologic tests with a subsequent histologic diagnosis of adenocarcinoma in situ or with early invasion, and 16 samples with negative results on follow-up. All samples were stained with CINtec PLUS p16/Ki-67 double stain. Of the neoplastic samples, 7 were excluded because of insufficient residual cellularity or loss of neoplastic cells. Of the samples that were adequate, 92.5% were stained with CINtec PLUS, whereas 7.5% were judged inconclusive. All inconclusive cases were at least 3 years old. Of the 16 negative samples, 15 (93.8%) stained negative and only 1 (6.2%) showed several positive clusters of cells. Our study shows that CINtec PLUS is a robust and useful tool for the diagnosis of glandular lesions of the cervix uteri.
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