期刊
AMERICAN JOURNAL OF CLINICAL PATHOLOGY
卷 138, 期 2, 页码 230-235出版社
OXFORD UNIV PRESS INC
DOI: 10.1309/AJCPDHQFNYJZ01YG
关键词
FoxP1; Non-small cell lung cancer; Tissue microarray; Immunohistochemistry; Prognosis
类别
资金
- Social Development and Applied Research Projects [S2010041]
- International Cooperation and Exchanges from the Department of Health Jiangsu Province
- Doctoral Fund of Affiliated Hospital of Nantong University, Nantong, China
FoxP1 has been reported to be expressed in several types of human malignant tumors, and has been associated with metastasis and patient prognosis. Quantitative real-time polymerase chain reaction (PCR) and immunohistochemical analysis with tissue microarray were used to characterize the expression of FoxP1 in non-small cell lung cancer (NSCLC). It was revealed that the expression of FoxP1 messenger RNA (mRNA) and protein was significantly higher in NSCLC tissue than in corresponding peritumoral tissue (P = .013 and P < .001, respectively). The expression of FoxP1 protein in NSCLC was related to gender, histologic type, and 5-year survival rate (all P < .05). Finally, we evaluated the prognostic significance of the expression of FoxP1 in a group of patients. Kaplan-Meier survival and Cox regression analyses showed that low expression of FoxP1 (P < .001) and later stage grouping by TNM (P = .022) were independent factors predicting poor prognosis for NSCLC.
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