期刊
AMERICAN JOURNAL OF CLINICAL PATHOLOGY
卷 137, 期 1, 页码 30-38出版社
AMER SOC CLINICAL PATHOLOGY
DOI: 10.1309/AJCP0QFQ0FTSZCPW
关键词
Bone marrow biopsy; Acute erythroid leukemia; Erythroid precursors; Immunohistochemistry; CD2-associated protein; Aldehyde dehydrogenase; ALDH; Carbonic anhydrase isoenzyme I
类别
Neoplastic elythroid proliferations may represent a diagnostic challenge owing to the difficulty in characterizing immature erythroblasts. Immunohistochemical expression of aldehyde dehydrogenase (ALDH), carbonic anhydrase isoenzyme I (CA 1), and CD2-associated protein (CD2AP) was assessed in 66 bone marrow biopsy specimens and compared with glycophorin A and E-cadherin. ALDH, CA I, and CD2AP labeled neoplastic erythroblasts in most acute erythroid leukemias (AELs) and myelodysplasias and highlighted benign erythroid precursors within normal marrows, erythroid hyperplasias, acute lymphoblastic leukemias (ALLs), blastic plasmacytoid dendritic cell neoplasm, and most acute myeloid leukemias (AMLs). In 2 AELs, CD2AP was negative, and 1 AML lacked identifiable ALDH+ erythroid precursors. Immature erythroblasts were strongly ALDH+, weakly CAI+, weakly CD2AP, E-cadherin, and weakly glycophorin A +/- AML was uncommonly weakly positive for ALDH, CAI and CD2AP, and lymphoblasts from 1 ALL were weakly ALDH+. ALDH, CA I, and CD2AP are sensitive and relatively specific immunohistochemical markers for the erythroid lineage. ALDH is superior to glycophorin A and E-cadherin in highlighting immature erythroblasts.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据