期刊
AMERICAN JOURNAL OF CLINICAL PATHOLOGY
卷 136, 期 5, 页码 696-704出版社
OXFORD UNIV PRESS INC
DOI: 10.1309/AJCP7UBK8IBVMVNR
关键词
Multiple sclerosis; Cytokines; Multiplexed assay
类别
We examined cytokines and other inflammatory markers in serum samples from 833 patients with multiple sclerosis and 117 healthy control subjects. A multiplexed immunoassay was used to assess the concentrations of 13 cytokines/inflammatory markers: interferon (IFN)-gamma; interleukins (ILs)-1 beta, 2, 4, 5, 6, 8, 10, 12, and 13; tumor necrosis factor (TNF)-alpha; IL-2 receptor; and soluble CD40 ligand. Significant increases between patients and control subjects were found for IFN-gamma (mean, 7.5 vs 0.4 pg/mL; P = .0002), IL-2 (mean 5.7 vs 1.0 pg/mL; P = .0002), IL-1 beta (mean, 23.0 vs 11.3 pg/mL; P <= .000I), TNF-alpha (mean, 4.1 vs 1.2 pg/mL; P = .01), IL-4 (mean, 1.4 vs 0.1 pg/mL; P <= .0001), IL-10 (mean, 16.8 vs 7.5 pg/mL; P = .03), and IL-13 (mean, 4.5 vs 0.8 pg/mL; P <= .0001). Profiling cytokines in multiple sclerosis may help to identify mechanisms involved in the pathogenesis of the disease, aid in monitoring the disease course and in evaluating responses to specific therapies, and, potentially, lead to new therapies directed at cytokines or their receptors.
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