期刊
AMERICAN JOURNAL OF CLINICAL PATHOLOGY
卷 133, 期 6, 页码 894-898出版社
AMER SOC CLINICAL PATHOLOGY
DOI: 10.1309/AJCPAZV88VIFZSFD
关键词
Human papillomavirus; HPV; Papanicolaou test; Negative for intraepithelial lesion or malignancy; NILM
类别
Cervical screening with combined cytology and high-risk human papillomavirus (HR-HPV) detection has been approved for women 30 years or older. We investigated the clinical use of cotesting for women with negative Papanicolaou tests. Follow-up cytology, HR-HPV test, and biopsy findings were identified during an 18-month period. In I year, 2,719 cotests from 2,686 women were identified,. 146 were positive for HR-HPV. Among women with positive HR-HPV testing, 120 had follow-up, including 70 with repeated cotesting, and 3 had high-grade dysplasia identified (2.5% of women with follow-up). In 1,334 women with initial double-negative cotest results who had repeated cytologic testing within 18 months, 2 high-grade dysplasias were found (0.1%). The vast majority of cotest results are double-negative. Among tests that show HR-HP V positivity, the prevalence of underlying high-grade dysplasia is low. About half of all women who undergo cotesting receive follow-up that is not in accord with published guidelines.
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