期刊
AMERICAN JOURNAL OF CLINICAL PATHOLOGY
卷 131, 期 2, 页码 257-263出版社
OXFORD UNIV PRESS INC
DOI: 10.1309/AJCP64YBDVCTIRWV
关键词
Glioblastoma; EGFR; p53; CDK4; Survival
类别
资金
- Fondo de Investigaciones Sanitarias, Madrid [FIS-0213006, PI070662, CA07100119, INT071028]
- FISCAM [PI-2006129]
- Consejeria dc Sanidad Junta de Comunidades de Castilla-La Manchu, Toledo [SESCAM 04032]
Primary glioblastoma multiforme (GBM), in contrast with secondary GBM, has been associated with the presence of EGFR amplification and absence of p53 mutation. In this study, we analyzed relevant molecular and clinical variables in 194 primary GBMs and tested them for survival analysis. Although most of the tumors showed a mutually exclusive pattern, concurrent alterations of EGFR and p53 were defected. Survival analysis of CDK4 amplfication revealed a high v significant association with a worse clinical outcome (P =.01), whereas MDM2, CDK6, PTEN, and p21 were not associated with patient survival. Multivariate analysis including the significant clinical and molecular variables revealed CDK4 amplification, age, and radiotherapy to be markers with independent prognostic value. In addition, the primary GBM tumors showing simultaneous EGFR and p53 alterations were significantly associated with worse survival (P <.01). These results highlight the prognostic value of CDK4 amplification and of simultaneous EGFR-p53 alterations in the clinical outcome of patients with primary GBM.
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