期刊
AMERICAN JOURNAL OF CLINICAL PATHOLOGY
卷 132, 期 1, 页码 125-132出版社
OXFORD UNIV PRESS INC
DOI: 10.1309/AJCPBRK7D1YIUWFP
关键词
Cervical neoplasia; Histology; Interobserver agreement; Cohen kappa; Cervical intraepithelial neoplasia
类别
资金
- European Union [SI.2.327046, SPC.20024 75]
- Italian Ministry of Health [L 13812004]
The reproducibility of cervical histology diagnoses is critical for efficient screening and to evaluate the effectiveness of new technologies. The vast majority of cervical intraepithelial neoplasia (CIN) diagnoses reported in the New Technologies for Cervical Cancer study were blindly reviewed by 2 independent pathologists. Only H&E-stained slides were used for the review. The reviewers were asked to reclassify cases using the following categories: normal CIN 1, CIN 2, CIN 3, and squamous and glandular invasive cancer. We reviewed 1, 003 cases. The interobserver agreement was 0.36 (95% confidence interval [CI], 0.32-0.40) with an unweighted kappa and 0.54 with a weighted kappa (95% CI, 0.50-0.58). The kappa values from dichotomous classifications with the threshold at CIN 2 were 0.69 (95% CI, 0.64-0.73) and 0.57 (95% CI, 0.51-0.63) with the threshold at CIN 3. The CIN 2 diagnosis had the lowest class-specific agreement, with fewer than 50% of cases confirmed the panel members, which supports the fact that CIN 2 is not a well-defined stage in the pathogenesis of cervical neoplasia.
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