期刊
AMERICAN JOURNAL OF CLINICAL PATHOLOGY
卷 129, 期 5, 页码 723-726出版社
OXFORD UNIV PRESS INC
DOI: 10.1309/CMPGPYTMFRM6RVQR
关键词
BCL2; c-MYC; fluorescence in situ hybridization; FISH; bone; B-cell lymphoma
类别
We selected a series of 63 primary diffuse large B-cell lymphomas (DLBCLs) of bone collected in tissue microarrays from centers in France and Brazil. These cases were classified according to the expression of antigens associated with germinal center (GC; n = 42) or non-GC (n = 21) stages of B-cell differentiation. By fluorescence in situ hybridization, we found a substantial number of cases with a rearrangement of BCL2 (9132) and c-MYC (n = 3), whereas the PAX5, BCL6, BCL1/cyclin D1, and ALK genes were in germline configuration. It is interesting that I case, with a GC phenotype, showed dual B CL2 and c-MYC rearrangement. The majority of the cases with rearrangements were of the GC phenotype. These results, associated with the lack of BCL6 rearrangement, suggest that bone DLBCL represents a specific group within extranodal B-cell lymphomas.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据