期刊
AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS
卷 31, 期 5, 页码 504-506出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/COC.0b013e3181844d1c
关键词
Breast cancer; qualitative age-interactions; early-onset; late-onset; low-risk; high-risk
类别
资金
- NIH
- National Cancer Institute
- NATIONAL CANCER INSTITUTE [ZIACP010183] Funding Source: NIH RePORTER
A qualitative age-interaction is defined as the reversal of relative risks or rates according to age at Onset. Once thought rare, qualitative age-interactions are commonly reported in studies that examine the etiology, prognosis, and treatment of breast cancer. Thus, nulliparity, obesity, and oral contraceptives decrease breast cancer risk in younger women but increase risk in older women. High-risk tumors are more common in younger women, whereas low-risk tumors are more common among the elderly, with bimodal peak frequencies at ages 50 and 70, respectively. Curves depicting the annual hazard of breast cancer death for women with high-risk (early-onset) and low-risk (late-onset) turners are shaped differently and move in opposite directions. Additionally, mammography screening and neo-adjuvant chemotherapy seem to have opposing effects in women with early and late-onset tumors. Taken together. these qualitative age-interactions may indicate that early and late-onset breast cancers are different diseases, derived from different pathways.
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