期刊
AMERICAN JOURNAL OF CLINICAL NUTRITION
卷 97, 期 5, 页码 1076-1082出版社
AMER SOC NUTRITION-ASN
DOI: 10.3945/ajcn.112.045575
关键词
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资金
- Ministry of Education, Culture, Sports, Science and Technology of Japan [22116010, 22240073, 22590892, 23590797, 23590798, 23500842, 24590797, 24590796]
- Health and Labour Sciences Research Grants of the Ministry of Health, Labour and Welfare of Japan [H20-Chouju-004, H22-Junkankitou-Ippan-005, H22-Junkankitou-Ippan-017, H23-Junkankitou-Ippan-002, H23-Junkankitou-Ippan-005, H23-Ninchisho-Ippan-004]
- Grants-in-Aid for Scientific Research [24590796, 25253048, 23590797, 22700297, 23500842, 24590797, 23590798, 22116010, 22240073, 22590621] Funding Source: KAKEN
Background: To our knowledge, there are no previous reports that assessed the association between dietary patterns and risk of dementia in Asian populations. Objective: We investigated dietary patterns and their potential association with risk of incident dementia in a general Japanese population. Design: A total of 1006 community-dwelling Japanese subjects without dementia, aged 60-79 y, were followed up for a median of 15 y. The reduced rank regression procedure was used to efficiently determine their dietary patterns. Estimated risk conferred by a particular dietary pattern on the development of dementia was computed by using a Cox proportional hazards model. Results: Seven dietary patterns were extracted; of these, dietary pattern 1 was correlated with high intakes of soybeans and soybean products, vegetables, algae, and milk and dairy products and a low intake of rice. During the follow-up, 271 subjects developed all-cause dementia. Of these individuals, 144 subjects had Alzheimer disease (AD), and 88 subjects had vascular dementia (VaD). After adjustment for potential confounders, risks of development of all-cause dementia, AD, and VaD were reduced by 0.66 (95% Cl: 0.46, 0.95), 0.65 (95% Cl: 0.40, 1.06), and 0.45 (95% CI: 0.22, 0.91), respectively, in subjects in the highest quartile of score for dietary pattern 1 compared with subjects in the lowest quartile. Conclusion: Our findings suggest that a higher adherence to a dietary pattern characterized by a high intake of soybeans and soybean products, vegetables, algae, and milk and dairy products and a low intake of rice is associated with reduced risk of dementia in the general Japanese population. Am J Clin Nutr 2013;97:1076-82.
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