期刊
AMERICAN JOURNAL OF CLINICAL NUTRITION
卷 96, 期 2, 页码 382-390出版社
OXFORD UNIV PRESS
DOI: 10.3945/ajcn.111.021907
关键词
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资金
- European Union [LSHM-CT-2006-037197]
- NL Agency grant [IGE05012]
- Incentive Grant from the Board of the UMC Utrecht (Netherlands)
- Dutch Ministry of Public Health, Welfare and Sports
- Netherlands Cancer Registry
- LK Research Funds
- Dutch Prevention Funds
- Dutch ZON
- World Cancer Research Fund
- Statistics Netherlands
- Cancer Research UK
- Swedish Research Council
- Novo Nordisk
- Swedish Heart Lung Foundation
- Swedish Diabetes Association
- Danish Cancer Society
- Deutsche Krebshilfe
- Associazione Italiana per la Ricerca sul Cancro
- Asturias Regional Government
- Health Research Fund of the Spanish Ministry of Health
- CIBER en Epidemiologia y Salud Publica (Spain)
- Murcia Regional Government
- AIRE-ONLUS Ragusa, AVIS-Ragusa, Sicilian Regional Government
- Medical Research Council [MC_U106179471, MC_UP_A100_1003] Funding Source: researchfish
- MRC [MC_UP_A100_1003] Funding Source: UKRI
Background: Dairy product intake may be inversely associated with risk of type 2 diabetes, but the evidence is inconclusive for total dairy products and sparse for types of dairy products. Objective: The objective was to investigate the prospective association of total dairy products and different dairy subtypes with incidence of diabetes in populations with marked variation of intake of these food groups. Design: A nested case-cohort within 8 European countries of the European Prospective Investigation into Cancer and Nutrition Study (n = 340,234; 3.99 million person-years of follow-up) included a random subcohort (n = 16,835) and incident diabetes cases (n = 12,403). Baseline dairy product intake was assessed by using dietary questionnaires. Country-specific Prentice-weighted Cox regression HRs were calculated and pooled by using a random-effects meta-analysis. Results: Intake of total dairy products was not associated with diabetes (HR for the comparison of the highest with the lowest quintile of total dairy products: 1.01; 95% CI: 0.83, 1.34; P-trend = 0.92) in an analysis adjusted for age, sex, BMI, diabetes risk factors, education, and dietary factors. Of the dairy subtypes, cheese intake tended to have an inverse association with diabetes (HR: 0.88; 95% CI: 0.76, 1.02; P-trend = 0.01), and a higher combined intake of fermented dairy products (cheese, yogurt, and thick fermented milk) was inversely associated with diabetes (HR: 0.88; 95% CI: 0.78, 0.99; P-trend = 0.02) in adjusted analyses that compared extreme quintiles: Conclusions: This. large prospective study found no association between total dairy product intake and diabetes risk. An inverse association of cheese intake and combined. fermented dairy product intake with diabetes is suggested, which merits further study. Ant J Clin Nutr 2012;96:382-90.
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