Protein supplementation lowers blood pressure in overweight adults: effect of dietary proteins on blood pressure (PROPRES), a randomized trial

Background: Dietary protein intake may help to manage blood pressure (BP) and prevent complications associated with elevated BR Objective: The objective of this study was to determine whether 4 wk of increased protein intake (similar to 25% compared with similar to 15% of energy intake that isoenergetically replaces carbohydrate intake) lowers office and daytime BP compared with increased carbohydrate intake. Design: A randomized, double-blind, parallel study compared consumption of 3 x 20 g protein/d (20% pea, 20% soy, 30% egg, and 30% milk-protein isolate) with 3 x 20 g maltodextrin/d. Protein or maltodextrin were isoenergetically substituted for a sugar-sweetened drink. Primary outcomes were office and daytime BP. A total of 99 men and women [age range: 20-70 y; BMI (in kg/m(2)): 25-35] with untreated elevated BP (BP >= 130/85 and <160/100 mm Hg) were randomly assigned. Ninety-four completers (51 subjects in the maltodextrin group, 43 subjects in the protein group) were included in the analyses. Results: Office systolic blood pressure (SBP) and diastolic blood pressure (DBP) were 4.9 +/- 1.7 mm Hg (P = 0.005) and 2.7 +/- 1.3 mm Hg (P = 0.05) lower, respectively, in the protein group. Daytime SBP was 4.6 +/- 1.7 mm Hg lower in the protein group (P=0.006), whereas daytime DBP did not differ between groups (P = 0.37). Urinary sodium excretion was higher in the maltodextrin group (P = 0.004). Conclusion: Increased protein intake, at the expense of maltodextrin, lowers BP in overweight adults with upper-range prehypertension and grade 1 hypertension. This trial was registered at www. trialregister.nl as NTR 1362. Am J Clin Nutr 2012;95:966-71.